Background: Patients who had cardiovascular disease (CVD) events in the past have fewer traditional risk factors to help them identify their risk. In this regard, measuring circulating biomarkers has been investigated as a potential method for determining event risk. Objective: To measure of viability of proneurotensin (pro-NT) as a good prediction for CVD among diabetic patients. Patients and methods: In the Internal Medicine Department's Outpatient Clinic and Endocrinology Unit at Zagazig University Hospitals, 84 type 2 diabetes mellitus cases were the subject of this case control research. They were equally subdivided into diabetic patients without coronary artery disease (CAD) and diabetic patients with established CAD.Results: Regarding the number of WBCs, there was a highly statistically significant difference between the examined groups. It was shown that diabetic patients with coronary artery disease had considerably higher cholesterol and LDL levels. In terms of proneurotensin, there was a statistically significant difference between the study groups. Pro-NT and cholesterol showed a strong positive link in patients with coronary artery disease, but HDL showed a substantial negative correlation in people without coronary artery disease. Pro-NT levels greater than or equal to 119.1 can be utilised to forecast when the condition will arise. Conclusion: To our knowledge, our work is the first to show a relationship between pro-NT levels and insulin resistance and their ability to predict the occurrence of CVD.