Background: Bladder cancer is a common genitourinary tumor in Egypt. Muscle invasive bladder cancer can be treated by bladder preservation protocol (BPP), which include maximum TURT, radiotherapy and chemotherapy. Eventually bladder preservation treatment could fail. Objective: To use Diffusion weighted MRI as a non-invasive test to predict response of tumor to BPP before the patient is exposed to the hazard of this therapy. Methods: We searched Science Direct, Google Scholar as well as PubMed for relevant articles on Muscle invasive, Bladder carcinoma andDiffusion weighted MRI. Only the most recent or thorough study was taken into account between 2004 and 2020. The authors also evaluated the value of resources culled from other works in the same genre. Documents written in languages other than English have been ignored due to lack of translation funds. Unpublished works, oral presentations, conference abstracts, and dissertations were generally agreed upon not to qualify as scientific research. Conclusion: Apparent diffusion coefficient (ADC) as an imaging biomarker is not recommended for routine clinical use due to a lack of standardisation and validation according to (EAU) guidelines, our small group study may be in need of extension on larger group of patients and the ADC values narrow band could be a curbed point of our work.