Background: A reduction in blood oxygen levels and periodic interruptions in breathing during sleep are hallmarks of obstructive sleep apnea (OSA). Objectives: to determine the amount of serum IL-8 in children diagnosed with OSA both before & after undergoing adenotonsillectomy. Patients and methods: Prospective randomized single-arm interventional trial. The research was conducted in the ENT Department of Suez Canal University Hospital, Ismailia City, Egypt. Children experiencing OSA and chronic intermittent hypoxia (CIH) signs during sleep. T & A was done on children as a matter of choice. Children's ages varied from three to twelve years old. Results: We found that there was significant variation among preoperative & postoperative IL-8. There was no significant distinction among preoperative & postoperative O₂ levels (p = 0.069), with the mean preoperative O₂ level being 98.27% and the mean postoperative O₂ level being 98.77%. The preoperative oxygen desaturation index (ODI) was significantly distinct from the postoperative ODI. The preoperative ODI had a mean value of 7.77, whereas the postoperative ODI had a mean value of 2.90. Conclusion: The levels of IL-8 in the children who had OSA were elevated. Children who had OSA showed a significant reduction in their IL-8 levels following adenotonsillectomy.