Background: Patients with diabetes mellitus commonly experience a diminished quality of life. The adoption of a sedentary lifestyle is well recognized as a risk factor that can be altered for the development of type 2 diabetes, as well as an independent indicator that predicts a diminished quality of life. Exercise plays a crucial role in the management of individuals having diabetes. Purpose: The objective of this investigation was to evaluate the impact of a selected physical therapy intervention on the quality of life among patients diagnosed with diabetic polyneuropathy.  Subjects and methods: Twenty patients were given selected physical therapy program for a total of 36 sessions spread out over 12 weeks at a rate of 3 sessions per week for a duration of 40 minutes each. All patients were evaluated with the Quality of Life scale (QoLS). The study was done in Outpatient Clinics of Faculty of Physical Therapy, Deraya University. Result: There was a substantial improvement in quality of life after treatment in the study group contrasted with that before treatment (p > 0.001). Conclusion: The findings of this study showed improvement of quality of life in patients that were given a selected physical therapy program (proprioceptive training, stretching as well as strengthening exercises for arm and leg muscles).