Background: While thoracic paravertebral nerve block (TPVB) is also frequently used for this purpose, transversus thoracic muscle plane-pectoral nerve block (TTP-PECS) is a unique and promising interfacial plane block that can give analgesia for modified radical mastectomy. Objective: This review article about the ultrasound-guided pectoral nerve block with transversus thoracic muscle plane block. Methods: We searched PubMed, Google Scholar, and Science Direct for relevant articles on Ultrasound-Guided Modified Pectoral Nerve Block and Transversus Thoracic Muscle Plane Block. Only the most recent or thorough study was taken into account between 2006 and 2020. Documents written in languages other than English have been ignored due to lack of translation funds. Unpublished works, oral presentations, conference abstracts, and dissertations were generally agreed upon not to qualify as scientific research. Conclusion: Strong analgesia is provided by thoracic paravertebral block, although it is technically difficult and carries the risk of consequences such as hypotension, pneumothorax, and spinal cord injury, but there are many controversies about the most effective, safe and simple regional analgesia techniques or modalities for cancer breast surgery.