Background: One of the most common cancers among Egyptian men is the cancer of bladder, representing about 16 % and accounting for more than 7900 deaths per year. This rate is far higher than that observed across the majority of worldwide. Aim and objective: This study aimed to examine the outcome of patients with urinary bladder cancer treated in the Oncology Department, Sohag University Hospital. Patients and Methods: This is a retrospective study conducted on patients with pathologically proven urinary bladder cancer treated in Oncology Department, Sohag University Hospital, from January 2016 to December 2020. Results: The six months, one-, two-, three- and five-years overall survival (OS) of all cohort of patients are 76.2%, 57.7%, 23.3%, 18.4% and 16.6% respectively. We found that there was an important relationship among OS and presence of pelvic pain, associated infiltration, receiving radiotherapy and radiotherapy toxicity, hydronephrosis, tumor size, (N & M) status, radiotherapy type, (P-value<0.05). Conclusion: The use of adjuvant radiation in the treatment of bladder cancer showed significant enhancements in both OS and disease-free survival (DFS). It is important to enhance community health awareness via the implementation of cultural programs and initiatives. These efforts aimed to disseminate knowledge about urinary bladder cancer, with the ultimate goal of facilitating early-stage detection and minimizing instances of late-stage diagnosis, which are often linked to hydronephrosis.