Background: A prevalent urologic illness in men, urethral stricture is accompanied by a significant financial burden as well as a decline in the quality of life for afflicted men and their families. Buccal mucosal grafts (BMG) are now often utilised to repair lengthy anterior urethral strictures. Objective: To assess the effectiveness of buccal mucosal graft urethroplasty for long-segment anterior urethral stricture resulting from various etiologies, including previously complex hypospadias repair. Patients and methods: This prospective cohort study included 65 patients with long-segment anterior urethral stricture due to different etiologies. Complete medical history and physical examination were done to each patient during enrollment. Urological investigations were done to confirm the diagnosis and to determine the accurate site of urethral stricture. All patients underwent buccal mucosal graft urethroplasty and all outcomes were reported. Results: The mean age of the patients was 27.6±13.15 SD years. Regarding the presenting symptoms, 63.1% of the panties complained from obstructive symptoms, and 39.9% complained from retention symptoms. Post hypospadias repair failure was the main etiology of strictures (n = 24; 36.9%). The success rate was found to be 84.6%, while 15.4% had recurrent stricture. The volume of blood loss was significantly affected success rate (P value=0.001). Also, the success rate was significantly affected by age (P value < 0.04), stricture site (P value < 0.006), cause of stricture (P value < 0.01), type of BMG urethroplasty (P value < 0.003), wound infection (P value < 0.001), hematoma formation (P value < 0.01), and catheterization time (P value < 0.001). Conclusion: BMG either dorsal or ventral onlay is an effective technique for treatment of urethral strictures of different etiologies.