Background: Bisphenol-A (BPA) may have a part in the aetiology of polycystic ovary syndrome (PCOS), or polycystic ovarian syndrome. BPA concentrations in biological fluids have been reported to be greater in PCOS women, and blood BPA levels in premenopausal women were associated with hepatic steatosis and indicators of low-grade inflammation. Objective: This research aimed to determine the relationship between blood levels of Bisphenol-A, an endocrine disrupting substance (EDC), and PCOS as well as its effects on the hormonal profiles of the PCOS group in comparison to the healthy control group. Subjects and methods: This cross-sectional study was carried out on 60 female participants who were selected from Outpatient Clinic of Obstetrics and Gynecology at Menoufia University Hospital and Damanhour National Medical Institute “The General Organization of Teaching Hospitals and Institutes through the period from August 2021 to January 2023. Results: The cutoff value of BPA sera levels in PCOS group was 12.50, with Sensitivity of 95% and Specificity of 85% at AUC of 0.590. Conclusion: BPA sera levels was correlated with different gynecological complications like infertility, abnormal uterine bleeding (AUB), hirsutism and different metabolic complications like DM and chronic HTN as a secondary outcome in PCOS group.