Background: Information provides knowledge, awareness, and power. Virtual organizations are developing and growing in every facet of our communities. Geographic boundaries are no longer a barrier for organizations. As virtual societies develop, it will be feasible to find answers to any questions at anytime, anywhere. Objective: The aim of the current study was to evaluate the impact of transition from paper forms to electronic forms and activation of Hospital Information System on increasing the speed and accuracy of workflow. Patients and methods: A cross sectional study included 50 staff members by evaluating the quality of service and staff learning obstacles before implementing Hospital Information System programs package during July and August 2022 and after implementing Hospital Information System programs package during February and March 2023 using formulated Key Performance Indicator to measure Internal Processes KPIs and Capacity KPIs and Customer Satisfaction KPIs. Results: A hospital information system seeks to improve workflow, clinical judgment, and data security as hospitals look to automate and optimize their activities. To increase overall profitability, a compliant cloud-based hospital management software system may contain a health billing platform with strong encryption, denial management capabilities, and multiple user components. Every hospital has different demands, therefore it's important to carefully analyze each one to lay a solid foundation for future success. Conclusion: Those results show that Hospital Management Information System represents a safe and effective tool to achieve significant improvement in work cycle time and decrease workload. Hospital Management Information System appears to have a real and significant impact on both workers and patient satisfaction in the form of decrease stuff absentee rate and increase patients' applause rate.