Background: The Klebsiella tribe is a subfamily of the Enterobacteriaceae family, which includes the Klebsiella genus. The organisms are named after the German microbiologist Edwin Klebs, who worked in the 19th century. Klebsiella are Gram-negative bacteria that are nonmotile and rod-shaped. Their polysaccharide capsule is easily recognizable. Carbapenems are a type of β-lactam antibiotic that are effective against a wide range of microorganisms, including both Gram-positive and Gram-negative bacteria, as well as aerobic and anaerobic strains. Objective: Review of the literature on Klebsiella pneumoniae carbapenemase detection methods. Methods: We looked for data on Klebsiella pneumoniae, detection methods in scholarly journals and databases including PubMed, Google Scholar, and Science Direct. Only, the most recent or extensive study published between May 2017 and May 2022 was taken into account. The writers also analyzed similar works cited in their work. Lack of resources to translate documents written in languages other than English has led to their neglect. It was generally recognized that scientific research did not include research that was not published in a peer-reviewed journal, presented orally, or presented as a conference abstract or dissertation. Conclusion: Implementing effective antibiotic therapy depends on the prompt and accurate laboratory detection of carbapenemase-producing bacteria. Disk-diffusion testing or increased minimum inhibitory concentrations (MICs) for carbapenems are typically used for screening for carbapenemase synthesis. A rapid turnaround time for carbapenemase detection technologies is desirable for prompt regulation. As discussed in Enterobacteriaceae and Acinetobacter baumannii, this could be complicated by the fact that MICs to carbapenems may be raised yet still within the susceptible range or even low.