Background: Acute kidney injury (AKI) is a common and preventable condition that affects 21% of adults and 33% of children globally, with higher mortality rates among the elderly and those with multiple comorbidities in developed countries. The lack of data on AKI in Africa may be due to limited access to renal replacement medication, and identifying high-risk individuals is crucial to avoiding the development of chronic kidney disease. Aim: The study aimed to evaluate patterns of AKI in Banha Teaching Hospital. Patients and Methods: The study collected data on patients aged 18 and older with AKI, including epidemiological, anamnestic, clinical, biological, imaging, treatment, and outcome data. AKI was defined according to the KDIGO classification and classified according to the mechanism of occurrence. Total and partial recovery was defined based on the evolution of renal function. Results: The study found that diabetes, coma, high creatinine levels, and sepsis were positively correlated with death occurrence. Gender, blood pressure, heart disease, and certain types of AKI did not show significant correlation with death occurrence. Conclusion: AKI is frequent among the population and often fatal, but can potentially be prevented by expanding extracellular volume to improve renal blood flow and decrease exposure to nephrotoxic agents.