Background: When an anesthesiologist with traditional training has trouble completing tracheal intubation, face mask ventilation of the upper airway, or both, this is referred to as a "difficult airway" (DA). The greatest danger is when treating the airways of patients who have been diagnosed with difficult mask ventilation (DMV) or who are anticipated to be problematic. Objective: To highlight for using particular techniques makes it easier to intubate a problematic airway. Methods: We searched PubMed, Google Scholar, and Science Direct for relevant articles on Difficult airway, assessment, Prediction and Management. Only the most recent or thorough study was taken into account between June 2003 and July 2020. Documents written in languages other than English have been ignored due to a lack of translation funds. Unpublished works, oral presentations, conference abstracts, and dissertations were generally agreed upon not to qualify as scientific research. Conclusion: Difficulty in intubation is a main problem encountered during general anesthesia that arise from anatomical and physiological barriers. Algorithm for airway management in DA is important to overcome possible complications.