Background:Testicular cancer (TC) is the most common cancer in young males, representing about ~1% of new cases of cancer in male patients around the world. Objective: The study aims to assess prognostic factors of testicular cancer, overall survival and progression free survival. Patients and Methods: Sixty patients with testicular cancer who had been attended to the Clinical Oncology and Nuclear Department at Mansoura University Hospitals between January 2006 and Desember2020 were included in this retrospective analysis. Results: The median age of the patients was 43 years. The most common presentation was testicular mass (71.7%). Cryptorchidism was presented in 7 cases (11.7%). Most of our patients were germ cell tumors 51cases (85%) divided into seminoma 34 patients (56.7%), nonseminoma17 patients (28.3%), 7 patient (11.7 %) were nongerm cell tumors and 2 patients (3.3%) were miscellaneous tumors. Regarding tumor, node and metastasis (TNM) staging, 43 patients (71.7%) were stage I, and 14 patients (23.3%) were stage III. Regarding lymph node metastasis, 57 patients (95%) were N0. All patients underwent high inguinal orchiectomy, (80%) of patients received chemotherapy, and 7 patients (11.7%) received radiotherapy. The 5 years overall survival was (91.7%) while 5 years progression free survival was (88.3%). Conclusion: Absence of cryptorchidism, germ cell tumors, node negative and stage I all are good prognostic factors.