Background: "A multifactorial unpleasant emotional experience of a psychological (cognitive, behavioral, and emotional), social, and/or spiritual nature that may impede with effective coping with cancer," is how the National Comprehensive Cancer Network (NCCN) describes cancer-related distress. Objective: Review of literature aboutDepression and anxiety in colorectal cancer patients. Methods: We searched PubMed, Google Scholar, and Science Direct for relevant articles on Depression, Anxiety and Colorectal cancer patients. Only the most recent or thorough studies were taken into account between October 2000 and May 2021. The authors also evaluated the value of resources culled from other works in the same genre. Documents written in languages other than English have been ignored due to a lack of translation funds. Unpublished works, oral presentations, conference abstracts, and dissertations were generally agreed upon not to be qualified as scientific research. Conclusion: A cancer diagnosis or recurrence, the start of a new treatment, or the course of an illness are all examples of times when anxiety is frequent. Resilience breakdown after trauma causes post-traumatic stress disorder. The disorder is characterised by an overwhelming anxiety of reliving the traumatic incident and is frequently accompanied by intrusive memories of the event, such as nightmares or flashbacks. Traumatized individuals frequently report feeling as though the terrible incident were occurring all over again during episodes of involuntary sensory flashbacks and nightmares.