Background: The majority of those who suffer from acne vulgaris are adolescents. In the preteen years, acne commonly occurs before a girl's menstrual period. About 85% of teens have acne, but it may also afflict people of all ages and last far into adulthood. Strong evidence supports the participation of follicular hyperkeratinization, hyperactivity of the sebaceous glands, colonisation of Propionibacterium acnes and yeast, and inflammation in the complicated etiology of acne.
Objective: To evaluate leptin level in non-obese females with acne vulgaris.  
Patients and Methods: This was a cross sectional study that was conducted in Helwan University (Badr) Hospital-Dermatology Clinic on 42 non-obese females with variable degrees of acne vulgaris, and 21 age compatible controls from people without any systemic disease, acne lesions, or medication. This study was conducted from August 2020 to July 2021.
Results: The current study demonstrated that the mean value of serum (S.) leptin was statistically higher among acne cases than control group (0.295; 0.233) P= 0.002. There was a non-statistically significant difference between severity in acne groups regarding S. leptin.
Conclusion: We found that acne vulgaris in non-obese females was associated with elevated serum leptin level compared to healthy controls. Our result supports the hypothesis that leptin may have a significant role in the pathogenesis of acne, especially in females. According to our findings, this association was not severity related.