Background: Urticaria is characterized by pruritic, well-circumscribed, variable-sized, erythematous wheals that can appear anywhere on the body. After a few hours, it typically disappears. Wheals, pruritus, and/or angioedema that last for more than six weeks characterise the common skin illness known as chronic urticaria (CU). Between 0.1% and 0.6% of the population suffers with urticaria associated with CU. Objective: Review of literature aboutchronic spontaneous urticaria from Medical Microbiology Background. Methods: We searched PubMed, Google Scholar, and Science Direct for relevant articles on chronic spontaneous urticaria. However, only the most recent or thorough study was taken into account between February 2013 and February 2022. The authors also evaluated the value of resources culled from other works in the same genre. Therefore, documents written in languages other than English have been ignored due to a lack of translation funds. Unpublished works, oral presentations, conference abstracts, and dissertations were generally agreed upon not to qualify as scientific research. Conclusion: Despite chronic spontaneous urticaria (CSU)'s low mortality rate, the disease's abrupt onset of varying symptoms over time and its chronic nature has a major negative effect on patients' health-related quality of life. Fatigue, soreness, disrupted sleep, and lack of focus are also typical symptoms, which are often linked to the persistent itching that comes with urticaria. Urticaria is an allergic reaction characterized by the development of angioedema, wheals (hives), or both. The severity of the illness must be noted in the patient's history, angioedema, dermographism, and other systemic symptoms how often they occur (abdominal discomfort, joint pain, and fever), in addition to the duration of the illness.