Background:''Neuron specific enolase'' (NSE) is, a dimeric iso-enzyme of the glycolytic enzyme enolase that is localized mostly in the neurons.
Aim: To assess the association between serum NSE levels with stroke severity.
Methods: The present study has been carried out on a total of 88 subjects, divided into three groups: G1 group, (29) ischemic stroke without hypertension and diabetes mellitus, while G2 group, (29) ischemic stroke with hypertension and diabetes mellitus, and control group (C), (30) healthy persons. Serum concentrations of ''NSE, random sugar, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea and electrolytes (Na, Ca, and K)'' for all participants were measured.
Results: The levels of random sugar, urea, ALT, AST, Na, K, Ca, RBCs, MCH, HCT and HGB were significantly increased in the C group compared to the G1 and G2 groups (p < /em>< 0.01).  Moreover, the NSE level was significantly increased in patients (G1 and G2 groups) compared to control group (51.94 14.16 ng/ml, 55.12 10.085 ng/ml and 14.29 1.98 ng/ml respectively). It can be concluded that serum NSE level may be used as an early detection marker of ischemic stroke patients.
Conclusion: Our result verifiedthat NSE serum levels during the early stages of an ischemic stroke can act as a useful marker to anticipate stroke, the intensity and quick functional consequence. Additionally, the various blood pressure factors are each independently linked to a higher risk of stroke in people with diabetes.
Keywords: Ischemic stroke, Diabetes mellitus, Hypertension, Neuron specific enolase.
Background:''Neuron specific enolase'' (NSE) is, a dimeric iso-enzyme of the glycolytic enzyme enolase that is localized mostly in the neurons.
Aim: To assess the association between serum NSE levels with stroke severity.
Methods: The present study has been carried out on a total of 88 subjects, divided into three groups: G1 group, (29) ischemic stroke without hypertension and diabetes mellitus, while G2 group, (29) ischemic stroke with hypertension and diabetes mellitus, and control group (C), (30) healthy persons. Serum concentrations of ''NSE, random sugar, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea and electrolytes (Na, Ca, and K)'' for all participants were measured.
Results: The levels of random sugar, urea, ALT, AST, Na, K, Ca, RBCs, MCH, HCT and HGB were significantly increased in the C group compared to the G1 and G2 groups (p < /em>< 0.01).  Moreover, the NSE level was significantly increased in patients (G1 and G2 groups) compared to control group (51.94 14.16 ng/ml, 55.12 10.085 ng/ml and 14.29 1.98 ng/ml respectively). It can be concluded that serum NSE level may be used as an early detection marker of ischemic stroke patients.
Conclusion: Our result verifiedthat NSE serum levels during the early stages of an ischemic stroke can act as a useful marker to anticipate stroke, the intensity and quick functional consequence. Additionally, the various blood pressure factors are each independently linked to a higher risk of stroke in people with diabetes.