303648

Fibroscan in Grading and Prediction of the Risk of Bleeding of Gastro-Esophageal Varices in HCV related Cirrhotic Patients

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Last updated: 03 Jan 2025

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Abstract

Background: By measuring liver stiffness (LS) with transient elastography (TE), portal hypertension and the presence of oesophageal varices (OV) were investigated. In HCV-related cirrhotic individuals, fibroscan is capable of predicting the presence of esophageal varices. And probable categorization based on degree of hepatic rigidity. Objective: This research aimed to use fibroscan and a prospective grade based on degree of liver stiffness as a means of diagnosing esophageal varices earlier in people with cirrhosis caused by HCV. Methods: Ultrasonography was used to evaluate 250 Egyptian HCV-related cirrhotic patients, aged >18, with a BMI of < 35 and no history of ascites, GIT hemorrhage, HCC, abdominal collaterals, portal or splenic vein thrombosis. They classified the varices as group I (no varices), group II (little varices), and group III (big varices). Results: All Groups were matched for age and BMI. In group III, Platelet count was lower & MELD was higher significantly than in groups I & II (115.4 ± 41.6 vs149.6 ± 60.6 & 132.1 ± 44.9 & 12.1 ± 2.9 vs 9.1 ± 2.5 & 10.1 ± 2.2 respectively. Mean LS in group I vs II & III was 20.5 ± 4.3 vs 40.5 ± 11.9 & 61.4 ± 13.1. Cutoff value for presence of OV:  27.3 Kpa (sensitivity 92.5% & specificity 98%), while LS cutoff value between group II & III: 40.9 Kpa (sensitivity 93% & specificity 52%). LS in bleeding vs none bleeding OV was 66.6 ± 10.5 vs 43.8 ± 18.8), cutoff value 55.7 Kpa (sensitivity 91.7% & specificity 73.5%). Conclusion: Liver cirrhosis patients may benefit from anticipating the existence of esophageal varices by evaluating liver stiffness using a fibroscan. It may also aid in selecting patients for endoscopic screening because other non-invasive criteria can't compare to its accuracy at predicting the size of esophageal varices.    

DOI

10.21608/ejhm.2023.303648

Keywords

FibroScan, Esophageal varices, Liver Stiffness, Splenic stiffness

Authors

First Name

Mohamed

Last Name

Omar

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Affiliation

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Email

m.omar84@yahoo.com

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Orcid

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First Name

Zakaria Abdellatif

Last Name

Salama

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Yasmin

Last Name

Saad

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Mohammed Mostafa

Last Name

Abdelghaffar

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Orcid

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Volume

91

Article Issue

1

Related Issue

40609

Issue Date

2023-04-01

Receive Date

2023-06-14

Publish Date

2023-04-01

Page Start

5,157

Page End

5,161

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_303648.html

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https://ejhm.journals.ekb.eg/service?article_code=303648

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216

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Fibroscan in Grading and Prediction of the Risk of Bleeding of Gastro-Esophageal Varices in HCV related Cirrhotic Patients

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Article

Created At

24 Dec 2024