Background: The administration of blood products in neonates has greater risk of harm when compared to that in adults so we must weigh up the benefits and hazards of blood transfusion in this vulnerable age group. Objective: To detect the incidence of adverse events of neonatal blood transfusion in Neonatal Intensive Care Unit (NICU) of Diarb Negm Central Hospital and Zagazig University Hospitals (Sednawi and Incident NICU). Subjects and Methods: In this study sixty cases of neonates admitted to incubators of Diarb Negm Central Hospital and Zagazig University Hospitals (Sednawi and Incident incubator) and received any blood element transfusion e.g., packed RBCs, platelets and fresh frozen plasma and remained for at least 48 hours after transfusion. All studied neonatal cases were subjected to the following investigations before transfusion CBC, CRP, ABG, liver and kidney function tests, coagulation profile and electrolytes. Then after transfusion, only CBC was done for all cases except the case who developed complication. Results: All cases received none previous blood transfusion. Majority of those neonates (75%) received packed RBC's transfusion followed by platelet (9%). RD in preterm and LBW was the most frequent disease in cases included in this study followed by congenital heart disease (13.3%) then bronchiolitis (11.67%) then sepsis (10%). Majority of cases were on CPAP (36.7%) followed by nasal catheter (28.3%) Conclusion: Packed RBCs is the most blood component transfused in neonates especially preterm. Transfusion of blood components is associated with several adverse reactions, both acute and delayed.