Background: The number of olfactory dysfunction cases resistant to the therapy increased after the pandemic of COVID-19, so platelet rich plasma (PRP) maybe effective. Objective: Assessment of role of platelet-rich plasma in managing olfactory dysfunction. Patients and methods: In a prospective study, twelve patient were recruited from the ENT Outpatient Clinic, Zagazig University Hospital. Each patient had been enrolled in two groups control side and injection side of platelet rich plasma. Anterior rhinoscopy, nasal endoscopy and CT scanning were done to all cases. Results: Both groups differed significantly regarding smell after intervention. Six patients of sides received PRP had normal smell and two patients had hyposmia, while four patients still had anosmia. No change was reported in control side in PRP group, there was significant improvement in smell, both groups differed significantly regarding smell improvement after intervention, no change was reported in control sides while 66.7% of PRP sides showed improvement in smell intensity, there was statistically significant relation between improvement in smell and etiology and disease duration. Genetic causes were associated with no improvement while post-viral was more liable for improvement after PRP. Longer disease duration is associated with no improvement. Conclusion: Platelet-rich plasma injection use in the olfactory cleft is easy and safe to be used to improve olfactory dysfunction especially in post viral cases.