Background: Parastomal hernia (PSH) is a frequent complication of end-colostomy following colonic cancer surgery. Putting a prosthetic mesh around the stomal opening is thought to decrease the incidence of parastomal hernia without an increase in the incidence of infection or other complications. Objectives: Our objective was to evaluate the efficacy of putting prosthetic mesh during end-colostomy to prevent parastomal hernia. Patients and Methods: One-hundred and four cases of colonic cancer at Menoufia University Hospital,Damanhour Oncology Center and Damanhour National Medical Institute were selected based on clinical diagnosis, ultrasonographic and laboratory findings for colonic cancer. They were divided into two groups: Group A; 52 patients of colonic cancer with end colostomy and Group B; 52 patients of colonic cancer with end colostomy and mesh enhancement. After positioning the stoma opening and its creation, we started to tailor the mesh and after tailoring; applied the mesh on the rectus sheath around the stomal end "subcutaneous, prerectus". Results: There was no statistically significant difference between patients of both groups regarding age or gender, family history of colonic cancer, tumor size, investigations, presence of ascites, length of the specimen, tumor stage, hospital stay, ICU admission, complications, early follow-up. While there was significant reduction in PSH and prolapse in mesh group. Conclusion: We can conclude that the use of mesh around the stoma opening can prevent complications especially prolapse and parastomal hernia.