Background: Intradialytic hypotension (IDH) is common complication in stage 5 chronic kidney disease patients on hemodialysis. Incidence ranges from 15 to 30%. Objective: This study aimed to check the effect of Na concentration, dialysate temperature on intra dialytic hypotension on regular hemodialysis patients. Patients and Methods: Our sample consist of 84 patient we divide them into 2 subgroups: Group 1 (Test group) included 42 patient. Group 2 included 42 patient (placebo). Group1 divided into: O L carnitine group 11 patient, O NA and temperature group (21 patient: (A: 7, B: 7 and C: 7). O WT based UF group (10 patient). Group 2 divided into: P1 (11 patients), P2 (21 patient: (A: 7 B: 7 C: 7). P3 (10 patient). All sub groups were monitored for 6 months. In order to know the effect of changing dialysate NA and temperature during hemodialysis session. In this paper we studied only changes to dialysate NA and temperature. Results: Regarding the mean Pre-HD SBP was 131.4 ± 17.56 in group Na, T. The mean Pre-HD DBP was 80.20 ± 9.19 in group Na, T. The mean Post-HD SBP was 119.23 ± 11.45 in group Na, T. The mean Pre-HD DBP was 71.20 ± 5.54 in group Na, T. The mean Pre-HD SBP was 130.15 ± 16.21 in group P. The mean Pre-HD DBP was 79.55 ± 8.22 in group P. The mean Post-HD SBP was 129.79 ± 15.23 in group P. The mean Pre-HD DBP was 76.78 ± 5.43 in group P. There were high significant difference between pre and post in Na, T group as regards SBP and DBP (mmHg). There were insignificant difference between pre- and post- in P group regarding SBP and DBP (mmHg). Conclusion: We found significant difference between subgroups regarding dialysate NA and T.