Background: An innovative supplement known as platelet-rich plasma (PRP) is being utilised more often to cure soft tissue deficiencies, speed up the regeneration of new soft tissue, and treat chronic wounds that won't heal. Objective: To evaluate the efficacy of injecting PRP in modulating the post burn scars at different stages. Patients and Methods: This study is a prospective study, carried out on 48 patients as 3 groups each group had 16 patients in Al Menoufia University Hospital and Ras Al Teen Hospital. The first group was from day zero of burn till 4 weeks, the second group from 4 weeks till the 12^th week and the third group from 12 weeks till the 6^th month. Results: Hyperpigmented scars in 7 (43.8%) of Groups I, II and III and they were improved with mean 2.00±0.816, 2.14±0.690 and 2.43±0.976 respectively. There were no statistically significant differences between the groups. Regarding depressed scars recorded in 2 (12.5%) of Group (I) and in 3 (18.8%) of group II, and in 1 (6.3%) of group III, they were improved with a mean of 4.00±0.000, 3.67±0.577 and 2.00±2.828 respectively. There were no statistically significant differences between the groups. While elevated scars were recorded in 8 (50.0%) of groups II and III, and 5 (31.1%) of Group (I). They were improved with a mean of 4.75±0.886 and 4.50±0.926, and 4.60±0.894 respectively, with no statistically significant differences between groups. Conclusion: The current study showed that the treatment of post-burn scars with intralesional injection of PRP seems to be safe and effective as well as cost-effective. Our results showed that PRP effects were affected by duration of scars as treatment after short duration from burns gave better effect.