Background: Intramedullary fixation offers a minimally invasive approach to the distal fibula with little palpable metalwork. When compared to a smooth pin, the long intramedullary screw provides superior purchase within the fibular canal. Objective: To evaluation of the clinical and radiological results of utilizing percutaneous intramedullary screw fixation for non-comminuted fractures of the lateral malleolus of the ankle. Subjects and Methods: This prospective study included twenty patients who had transverse or short oblique Weber A or B lateral malleolus fractures and were treated with closed reduction and percutaneous internal fixation using a fully threaded, self-tapping screw (3.5 mm) and a washer. At least 6 months of follow-up was conducted. Results: There was significant statistical relation between the final clinical and radiological results as well as with associated medial malleolus fracture. While age, gender, side of injury, type of fracture, pattern of fracture, associated co- morbidities and screw length had no statistical significance. Both a rotational malunited lateral malleolus fracture and a superficial infection at the incision site occurred in 5% of patients. Conclusion: By avoiding extensive soft-tissue dissection, closed reduction reduces the risk of postoperative wound problems and hardware-related pain. The 80 mm to 100 mm range of screw length measures made it possible for the 3.5 mm little set screw utilised in this investigation to gain a purchase within the fibular medullary canal. The distal fibular bow was accommodated by the screw's pliability, and three points of contact were established within the fibular medullary canal.