Beta
301580

Effect of Subconjunctival Injection of Bevacizumab in Preventing Recurrence of Pterygium before and after Surgical Removal

Article

Last updated: 24 Dec 2024

Subjects

-

Tags

-

Abstract

Background:   Recurrence, which is indicated by the expansion of fibrovascular tissue past the limbus and onto the cornea, is the main worry in pterygium surgery. Several techniques have been put forth to slow the pace of recurrence. Pterygium recurrences typically occur within the first three months following surgery. Objective: To evaluate the efficacy of a protocol based on applying two 2.5 mg/ml bevacizumab injections, before and after surgery, as adjuvant therapy of surgical pterygium excision to assess its role in preventing the recurrence of pterygium. Patients and Methods: A randomized control study was conducted on 84 patients. Complete ophthalmic examinations were performed on all patients, including the following: history, visual acuity, slit lamp examination, intraocular pressure (IOP) measurement, fundus examination, and Refraction by Auto refractometer. Results: The recurrence rate was significantly lower in the group that underwent pre- and postoperative bevacizumab injection. Moreover, we observed improvements in dimensions and vascularization of pterygium one week after the first subconjunctival injection. In our study, there were some postoperative complications; most of them in the pretreated group were related to pterygium surgery, such as subconjunctival hemorrhage, photophobia, and conjunctival injection. All of these complications occurred in both groups, but with the use of bevacizumab the field was less vascular, and the subconjunctival hemorrhage was less remarkable in the pretreated group than in the control group. Conclusion: Dimensions and vascularization of pterygium significantly decreased one week after the first subconjunctival bevacizumab injection. The recurrence rate was significantly decreased in the group that underwent pre- and postoperative bevacizumab injection.  

DOI

10.21608/ejhm.2023.301580

Keywords

Subconjunctival injection, Bevacizumab, Recurrence, Pterygium, Surgical removal

Authors

First Name

Hussien Salah Eldin

Last Name

Elnahas

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Mervat Elshabrawy

Last Name

Elgharieb

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Amr Abdelfattah

Last Name

Gaballah

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

First Name

Ahmed Ragab Hafez

Last Name

Ahmed

MiddleName

-

Affiliation

-

Email

ahmed.ragabhafez@yahoo.com

City

-

Orcid

-

Volume

91

Article Issue

1

Related Issue

40609

Issue Date

2023-04-01

Receive Date

2023-06-01

Publish Date

2023-04-01

Page Start

4,928

Page End

4,932

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_301580.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=301580

Order

181

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of Subconjunctival Injection of Bevacizumab in Preventing Recurrence of Pterygium before and after Surgical Removal

Details

Type

Article

Created At

24 Dec 2024