Background: Ten percent to fifteen percent of all persons have chronic kidney disease (CKD). The global diabetes epidemic is expected to substantially raise the incidence of this crippling illness. Adjusting to any chronic illness can be difficult. Coping with treatment transitions or failures, learning to use dialysis equipment, incorporating treatment into one's normal life, and accepting the life-threatening diagnosis are all part of the process. Patients with CKD need to make mental adaptations to deal with the disease, its symptoms, and its repercussions. Objective: Review of correlation between depression and end-stage renal disease. Methods: We scoured scholarly papers and databases including PubMed, Google Scholar, and Science Direct for information on depression and end-stage renal disease. Between August 2003 and March 2020, however, only the latest or most comprehensive study was considered. The authors also assessed the usefulness of references taken from similar books. Documents written in languages other than English have been overlooked because of a lack of funding to translate them. Unpublished articles, oral talks, conference abstracts, and dissertations were all generally agreed upon to not constitute valid scientific investigation. Conclusion: Depression is common among adults with ESRD and it has been connected to the physiological and psychological changes that take place during dialysis treatment. Recent studies have shown that patients who had CKD being managed by dialysis are at up to three times the risk of developing depression as the general population.