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300796

Assessment of Possible Role of Renin Angiotensin Aldosterone System in Obesity: Review Article

Article

Last updated: 03 Jan 2025

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Abstract

Background: There has been a dramatic rise in the prevalence of obesity around the world, and it is now recognized as a major contributor to health problems. Secondary negative health issues, such as high blood pressure, cardiovascular disease, and type 2 diabetes, are more likely to affect those who are overweight and obese. Body fluid regulation and cardiovascular homeostasis are traditionally attributed to the renin-angiotensin-aldosterone system (RAAS), which is a hormone system. Recent studies have revealed the presence of active RAAS in many different tissues. Adipose tissue is one of these tissues where the RAAS has been found to have functional components. Objective: Assessment of renin angiotensin aldosterone possible role in obesity. Methods: PubMed, Google Scholar, and Science Direct were used to search for the terms angiotensin, obesity, and renin-angiotensin-aldosterone system. Although they only looked at the most recent or comprehensive study from July 2003 to July 2022, the authors also looked at references from relevant literature. Documents produced in languages other than English have been rendered invalid due to lack of translation-related information. Dissertations, oral presentations, unpublished publications, conference abstracts, and other items that did not deal with significant scientific research were all ignored. Conclusion: Experiments suggest that the processes that drive adipose tissue development and metabolism in peripheral organs, as well as the effects of angiotensin on appetite and metabolism, contribute to the increased activity of the renin-angiotensin system in obesity. Although renin angiotensin aldosterone system antagonists are typically used to treat high blood pressure and heart failure, there is growing evidence that they may also be useful in managing obesity and other metabolic diseases.  

DOI

10.21608/ejhm.2023.300796

Keywords

angiotensin, Obesity, Renin angiotensin aldosterone system

Authors

First Name

Rabab Saber

Last Name

El.Sebaey

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Email

drrababsaber93@gmail.com

City

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Orcid

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First Name

Heba A.

Last Name

Hassan

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Noha A. T.

Last Name

Abbas

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Fawkia A.

Last Name

Fayed

MiddleName

-

Affiliation

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Email

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City

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Orcid

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Volume

91

Article Issue

1

Related Issue

40609

Issue Date

2023-04-01

Receive Date

2023-05-28

Publish Date

2023-04-01

Page Start

4,828

Page End

4,831

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_300796.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=300796

Order

165

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Assessment of Possible Role of Renin Angiotensin Aldosterone System in Obesity: Review Article

Details

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Article

Created At

24 Dec 2024