299486

Possible Role of Vitamin D in the Pathogenesis of Lichen Planus: Review Article

Article

Last updated: 03 Jan 2025

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Abstract

Background: The skin, mucosa, and extremities can be affected by lichen planus (LP), a chronic lichenoid inflammatory condition. Rich inflammatory T cells infiltration, which travel in a band-like pattern in the upper section of the dermis, is a characteristic hallmark of LP. There have been numerous descriptions of the disease's various subtypes. Vitamin D regulates immunological function, making it a key factor in the development and progression of LP. Objective: Review of possible role of vitamin D in the pathogenesis of Lichen Planus. Methods: We scoured scholarly papers and databases including PubMed, Google Scholar, and Science Direct for information on Lichen Planus and vitamin D between May 1986 and January 2022, however only the latest or most comprehensive study was considered. The authors also assessed the usefulness of references taken from similar books. Documents written in languages other than English have been overlooked because of a lack of funding to translate them. Unpublished articles, oral talks, conference abstracts, and dissertations were all generally agreed upon to not constitute valid scientific investigation. Conclusion: Vitamin D deficiency reduces Th2 cells and other T cells that are included among inflammation processes like T helper cells 11 and 17. This makes a bad situation much worse in inflammatory disorders like Lichen Planus.  

DOI

10.21608/ejhm.2023.299486

Keywords

Vitamin D, lichen planus

Authors

First Name

Nagwa Ali

Last Name

Diab

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Orcid

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First Name

Abdallah Mohamed

Last Name

Esawy

MiddleName

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Affiliation

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Email

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Orcid

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First Name

Youmna Mostafa

Last Name

Gabr

MiddleName

-

Affiliation

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Email

dr.youmna.derma@gmail.com

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Volume

91

Article Issue

1

Related Issue

40609

Issue Date

2023-04-01

Receive Date

2023-05-18

Publish Date

2023-04-01

Page Start

4,701

Page End

4,706

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_299486.html

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https://ejhm.journals.ekb.eg/service?article_code=299486

Order

146

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Possible Role of Vitamin D in the Pathogenesis of Lichen Planus: Review Article

Details

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Article

Created At

24 Dec 2024