Background: Asthma is a major health problem. Increases the price tag as well as the number of people affected by it. The pathogenesis of allergic asthma has been linked to a number of genes. The FOXP3 gene have recently been studied for their potential relevance in the protection against development of allergic asthma. Objective: Assessment of possible importance of Forkhead Box Protein P3 (FOXP3) among Allergic Asthma. Methods: PubMed, Google Scholar, and Science Direct were scoured for information on FOXP3, polymorphism, and allergic asthma. The authors also reviewed the relevant literature, however only the most recent or comprehensive studies from December 2005 to January 2022 were included. Documents written in languages other than English have been disregarded because translation resources are inadequate. Unpublished articles, oral presentations, conference abstracts, and dissertations were not included because they were not considered to be part of major scientific projects. Conclusion: The FOXP3 gene located on Xp11.23 has a great importance in immune hemostasis and prevention of a wide variety of diseases, including a number of allergy-related conditions. Therefore, it appears to prevent allergic disease, however, additional research is needed to determine how it affects asthma.