Background: Percutaneous coronary intervention (PCI) may be complicated by contrast-induced acute kidney injury (CI-AKI). The current study aimed to evaluate the pre-contrast hemogram-derived indices as early predictors for CI-AKI after PCI. Methods: A case-control study involved 54 patients who underwent PCI, divided into Group I (27 patients with no CI-AKI), and Group II (27 patients with CI-AKI). After the history taking, examination and routine laboratory investigations, the pre-contrast hemogram-derived indices were calculated; neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR), neutrophil / platelet ratio (NPR), monocyte / lymphocyte ratio (MLR), eosinophil / lymphocyte ratio (ELR), and systemic immune-inflammation (SII) index (platelet count × (neutrophil count / lymphocyte count). Results: There were significantly higher pre-contrast leucocytes, neutrophils, NLR (p˂0.001) (HS), MLR, PLR, NPR, ELR, and SII in group II than in group I (p˂0.05). The ROC analysis showed a significant predictive value for pre-contrast NLR (92.8% sensitivity & 51.3% specificity), NPR (42.8% & 86.4%), and SII (53.5% & 81.1%), MLR (85.7% & 43.2%), and ELR (50% & 78.3%). The odds ratios (OR) for pre-contrast hemogram-induced indices as predictors for CI-AKI, with confidence interval (CI) 95% were as follows; NLR OR (2.12), CI (0.71-6.31); PLR OR (2.11), CI (0.71-6.26); SII OR (2.96), CI (0.96-9.11); MLR OR (2.89), CI (0.95-8.72); ELR OR (3.4), CI (1.11-10.4); NPR OR (2.5), CI (0.82-7.53); RDW OR (2.12), CI (0.71-6.31). Conclusion: Hemogram-derived indices including pre-contrast SII, NLR, NPR, and MLR may be useful early predictors for CI-AKI after PCI.