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296395

Serum suPAR and Urinary Nephrin as Novel Sensitive and Specific Markers for Diabetic Nephropathy in Patients with Type 2 DM

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Last updated: 03 Jan 2025

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Abstract

Background: The most frequent reason of end-stage kidney disease (ESKD) is diabetic nephropathy (DN), highlighting the need of early detection, treatment, and prevention. Objective: To assess the sensitivity and specificity of serum (soluble urokinase-type plasminogen activator receptor (suPAR) and urinary nephrin in cases with type 2 diabetes mellitus (T2DM) with and without nephropathy. Methods: This prospective study was conducted on 70 patients of T2DM and 15 healthy control group of age and sex matched persons. All patients and control group were subjected to pelviabdominal U/S, laboratory investigations (CBC, ESR, liver and kidney function test, fasting and 2 hours post prandial blood sugar, urine analysis, (urine albumin creatinine ratio (UACR), nephrin, and serum suPAR levels). Results: ROC analysis was done for suPAR to predict DN. It showed a significant AUC of 0.869, with a 95% CI ranging from 0.785 – 0.953 (P < 0.001). The best cutoff was > 82.3, at which sensitivity and specificity were 97.1% and 68.6%, respectively. ROC analysis was done for urinary nephrin to predict DN. It showed a significant AUC of 0.760, with a 95% CI ranging from 0.642 – 0.877 (P < 0.001). The best cutoff was > 10.8, at which sensitivity and specificity were 80% and 68.6%, respectively. Conclusions: In T2DM patients, serum suPAR and urinary nephrin were more specific and sensitive markers than microalbuminuria in early detection of DN.  

DOI

10.21608/ejhm.2023.296395

Keywords

Serum suPAR, Urinary Nephrin, diabetic nephropathy, Type 2 DM

Authors

First Name

Amr M.

Last Name

Elhammady

MiddleName

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Affiliation

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Email

hend.elshafie@fmed.bu.edu.eg

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Orcid

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First Name

Hend S.

Last Name

ELShafie

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Asmaa A.

Last Name

El Fallah

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Medhat A.

Last Name

Khalil

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-

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Volume

91

Article Issue

1

Related Issue

40609

Issue Date

2023-04-01

Receive Date

2023-04-24

Publish Date

2023-04-01

Page Start

4,373

Page End

4,379

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 91_Issue 1_Pages 4373-4379.pdf

PDF . 354.1kB

Link

https://ejhm.journals.ekb.eg/article_296395.html

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https://ejhm.journals.ekb.eg/service?article_code=296395

Order

91

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Serum suPAR and Urinary Nephrin as Novel Sensitive and Specific Markers for Diabetic Nephropathy in Patients with Type 2 DM

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Article

Created At

24 Dec 2024