Background: Both benign and malignant diseases now have more and more justifications for laparoscopic splenectomy, which is currently considered a standard technique for handling practically all disorders necessitating splenectomy. Objective: We aimed to contrast the consequences of benign versus malignant hematological diseases following laparoscopic splenectomy. Patients and Methods: We carried out seventy-six laparoscopic splenectomies between 2019 and 2022. 38 patients were handled with the use of a unique method, an anterior approach, but 38 patients have been positioned in a semi-lateral position for laparoscopic intervention. Result: Malignant disorder patients had older ages (60.1), whereas benign disorder sufferers had younger ages (35.6), P = 0.001. Laparoscopy was used in 72 of 76 cases (94.7%). Four situations (5.2%) have been modified to open cases. Operative time used to be 2.51 h/min for malignant in distinction to 2.30 h/min for benign tumors (P > 0.05). Conclusions: laparoscopic splenectomy is logically appropriate as a less invasive technique for benign splenomegaly, hematological tumors, or both.