Background: Eighty percent or more of teenagers will experience acne. The acne scars left behind by acne vulgaris are irreversible. Up to 95% of people with acne vulgaris may experience scarring, yet this issue has received little attention from researchers. Depending on the study, acne scars affect between 1% and 11% of the population. Lasers have great potential as a therapeutic tool, but it has been difficult to get desirable clinical results because of the inherent trade-off between efficiency and safety, especially with the first generation of ablative lasers. Current research suggests that topical insulin may be effective in reducing the appearance of acne scars. Increased VEGF is produced after topical insulin activates PI3K/AKT pathways. Unlike the crisscross pattern typical of scar tissue, the collagen fibres generated and developed in normal skin more closely resemble a "basket weave. “. Objective: Assessment of possible role oftopical insulin and fractional laser in the treatment of acne scars. Methods: PubMed, Google Scholar, and Science Direct were scoured for information about: Acne scars, fractional laser therapy and topical insulin. The authors also reviewed additional sources, but only the most up-to-date or comprehensive study between April 2004 and April 2021 was included. There are no translation resources available, thus non-English documents are out. Dissertations, conference papers, and oral presentations were not included since they do not constitute "important scientific discoveries." Conclusion: It's possible that post-acne scars can be effectively treated with either topical insulin or fractional laser. Larger controlled studies are needed to confirm the effectiveness of insulin as a novel anti-scarring medication.