Background: The preferred course of treatment for symptomatic gallstone disease includes cholecystectomy due to both therapeutic reasons and secondary prevention of recurring gallstone-related problems. Objectives: This study examined the effectiveness, safety, and practicability of three- and four-port lap cholecystectomy: The intraoperative and postoperative complications of 3 port and 4 port lap cholecystectomies are compared: Days spent in the hospital, or operational time. Intraoperative and postoperative complications, as well as postoperative pain {by VAS   visual analog scale}. Patients and methods: At Assiut University Hospitals' Department of General Surgery, a randomized controlled study was done. Results: Both groups had significant difference (p> 0.001) as regard patient's satisfaction where good, average and poor satisfaction present in 47 (94%), 2 (4%) and 1 (2%) patients of 3-port Laparoscopic Cholecystectomy (LC) group and present in 27 (54%), 21 (42%) and 2 (4%) patients of 4-port LC group < strong>. Conclusion: Three in terms of procedure and morbidity outcomes, the one-port laparoscopic cholecystectomy is comparable to the four-port approach. Additionally, it might lead to less postoperative discomfort, a shorter stay in the hospital, and a quicker return to normal activities.