Background: Strokes are the second-most frequent reason of dementia and the most frequent reason of physical impairment. In addition, most survivors develop motor impairments that affect their quality of life and capability to perform activities of daily living. Objective: This study aims to show if respiratory muscle training by the breather could enhance the quality of life in post-stroke patients. Material and methods: Fifty stroke patients were assigned into two groups. Both groups were engaged in conventional rehabilitation three times per week for six weeks. The experimental group performed respiratory muscle training (RMT) by the breather at a rate of five breaths per set, five sets/session, twice daily. The intensity was approximately 60% of the maximum effort. Data about quality of life assessed through the stroke impact scale were taken before and after six weeks. Results: Both groups achieved significant improvement in physical, emotional, and social memory, communication, and stroke recovery of SIS, but there was no significant difference between the two groups. Conclusions: Adding a breather to conventional rehabilitation of stroke patients produces a non-significant effect on the quality of post-stroke life.