Background: Age, heart failure, and hypertension are a few clinical characteristics that are separately linked to structural and electrical remodeling of the left atrium and make up the CHA2DS2-VASc index. In patients without atrial fibrillation (AF), remodeling and dysfunction are those of the left atrium (LA). The likelihood of stroke risk factors including atrial fibrillation. Objective: This review's objective was to assess the prognosis and thromboembolic risk that patients with HFpEF are predicted by the CHA2DS2-VASc score. Methods: We looked for data on Heart Failure, Hypertension, Atrial Fibrillation and Left Atrium in medical journals and databases like PubMed, Google Scholar, and Science Direct. However, only the most recent or extensive study was taken into account between February 2004 and September 2022. References from related works were also evaluated by the writers. There are not enough resources to translate documents into languages other than English, hence those documents have been ignored. It was generally agreed that documents such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations did not qualify as legitimate scientific study. Conclusion: CHA2DS2-VASc scores are simple to calculate, easy to remember, and reductionist. Utilizing the score in people with sinus rhythm can speed up clinical evaluation and help identify people who are particularly at risk of stroke.