Background: Congenital heart disease (CHD) in neonatal population remains a major health problem that requires more attention. Currently, most of the data came from high income countries which can't represent the situation in low-income countries. Objectives:The aim of the current work was to evaluate in-hospital outcomes of neonates who were admitted to neonatal intensive care unit, Ain Shams University Specialized Hospital (ASUSH) with a cardiac anomaly requiring intervention as their main cause of admission. Methodology: Electronic medical records of enrolled neonates were retrieved, reviewed, and analyzed over a period of 18 months. The outcomes of in-hospital mortality, length of stay, duration of mechanical ventilation, and postoperative complications were evaluated. Results: Twenty-nine patients were identified; 10 females (34.5%) and 19 males (65.5%). 82.8% were full terms, with median admission age of 60 days. 65.5% (19/29) patients had coarctation of the aorta (COA). Twenty-eight patients (96.6%) underwent cardiac surgery. 100% of patients with Fallot tetralogy and double outlet right ventricle (DORV) received palliative surgery, while 94.7% (18/19) of patients with COA had corrective surgery. Overall mortality was 6.9% (2/29).  Twenty-four patients required postoperative mechanical ventilation (range 1-41 days). 24/29 (82%) had uncomplicated stay, one patient had pneumothorax and four patients (13.8%) had sepsis. Conclusion: It could be concluded that early outcomes of cardiac surgery in the Intensive Care Unit of Ain Shams University Specialized Hospital (ASUSH) appear to be satisfactory.