Background: Common systemic diseases are often mirrored in the skin condition known as acanthosis nigricans (AN). There may be a connection between this and insulin resistance, diabetes, adverse drug reactions, endocrine problems, internal cancer, as well as obesity. Objective: Review of the literature on management methods of Acanthosis Nigricans. Methods: We looked for data on Acanthosis Nigricans, Obesity and diabetes, Hyperinsulinemia, and Skin, in medical journals and databases like PubMed, Google Scholar, and Science Direct. However, only the most recent or extensive study was taken into account between February 2004 and September 2022. References from related works were also evaluated by the writers. There are not enough resources to translate documents into languages other than English, hence those documents have been ignored. It was generally agreed that documents such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations did not qualify as legitimate scientific study. Conclusion: An important goal of treatment for AN should be to diagnose and treat the underlying cause of the disorder. When it comes to obesity-related AN, hyperkeratotic lesions may clear up if the patient loses enough weight, and hyperinsulinemia can be alleviated with dietary and lifestyle changes. When treating AN, topical retinoids are often among the first choices considered, especially for unilateral nevoid AN. Some people who suffer from AN have found relief from using superficial chemical peels. Trichloroacetic acid (TCA) is a stable molecule, making it easy to judge the endpoint of its exfoliation. It is also non-toxic, inexpensive, and easy to manufacture.