Background: A lot of studies investigated the role of sonography and nerve conduction velocity for diagnosis of median nerve pathology. The data were examined to draw conclusions on the clinical performance of ultrasound as a screening tool to replace electrophysiological studies and to propose further and future study. There is a lot of opportunity for clinical screening in the region of the carpal tunnel where the median nerve has its largest cross-section. Further analysis is required to determine whether nerve swelling can be detected using comparison measures and doppler methods. Objective: To assess the accuracy of ultrasonography and nerve conduction velocity in diagnosing median nerve entrapment.Data Sources: Medline databases (PubMed, Medscape, ScienceDirect. EMF-Portal) and all materials available in the Internet till 2023. Conclusion: In confirming a diagnosis of carpal tunnel syndrome (CTS), nerve conduction studies (NCS) is more sensitive than US. Due to US's strong positive predictive value, one can think of utilizing it as a screening test instead of NCS in the majority of cases when there is clinical suspicion of CTS. NCS would then only be used in cases where US is negative.