Background: Laparoscopic surgery is increasingly popular for difficult and oncologic treatments, in addition to straightforward ones. Recent developments in minimally invasive surgery and surgical technique result in a shorter hospital stay, decreased mortality, less analgesic use, and improved cosmetic outcomes as compared to open surgery. Objective: The aim of the current study is to identify the predictive factors (etiology, demographic data and clinical characteristics) on the prognosis of laparoscopic nephrectomy for hydronephrotic non-functioning kidneys. Patients and methods: A one-arm clinical trial was conducted at Fayoum University Hospital. A total of 40 patients underwent laparoscopic nephrectomy for hydronephrotic non-functioning kidneys. All participants were subjected to history taking and complete clinical examination to determine their suitability for laparoscopic surgery. Results: Age, sex, the side of the resected kidney and high serum creatinine levels did not significantly affect the success of the laparoscopic nephrectomy. A significant improvement was observed in the operative time, and preventing intra- and postoperative complications. Conclusion: Turbid content of the pelvicalyceal system and history of prior urological intervention were the most important predictive factors for bad prognosis of laparoscopic nephrectomy for hydronephrotic non-functioning kidneys.