Background: About 39-59% of individuals with idiopathic intracranial hypertension (IIH) have cranial nerve impairments of some kind, including single or multiple cranial nerve (CN) palsies. Objective: The aim of the current study was to assess clinical outcome after cerebrospinal fluid (CSF) tapping through blink reflex (BR). Patients and methods: A comparative study was carried out on 40 female patients with IIH, aged between 18 and 60 years, and 40 age and sex matched normal volunteers as a control group, between 2019 and 2021. Participants were subjected to blink reflex before and after therapeutic CSF tapping at Neuro-Diagnostic & Research Center (NDRC), Beni-Suef University Hospital. Results: Patients with IIH after CSF tapping showed significant decrease of latencies of BR {the ipsilateral R2 (R2i) from 31.6 (2.8) to 30.6 (2.1) ms (P=0.019) and contralateral R2 (R2c) from 35.2 (3.3) to 33.8 (2.5) ms (P=0.023). After CSF tapping, when compared patients to controls, the latencies of R2i 30.6 (2.1) to 29 (2.6) ms (P=0.005) and R2c 33.8 (2.5) to 32.2 (2.8) ms (P=0.007).