Background: Diabetes Mellitus is a chronic condition that happens when the pancreas fails to produce sufficient insulin or when the body's insulin production is ineffective. Objectives: This study's aim was to investigate into the effects of Diabetes serum oxidants and antioxidants . Materials and Methods: Samples of blood were taken from (50) patients with diabetes  , furthermore (50) healthy individuals served as the control group.. Those who participated were separated into two groups as follows:Group (control), consist of fifty healthy individuals aged (20-70years) and fifty people with diabetes were included in the patient group (20-70 years). The study included 45% females and 55% males. Regarding each group, 52% of participant in control group were males and 48% were females while in patients 58% were males and 42% were females. Marker for the lipid profile, The mean difference of fasting blood sugar, HbA1c and preventative antioxidants Total Protein, Albumin, Globulins, Albumin/Globulins ratio, serum urea, serum creatinine and Uric acid patients with diabetes  were done. Results:The findings indicate that there has been a significant increase in the level of FBS, HbA1c, TC, TG, LDL, VLDL, urea, creatinine and uric acid in patients groups  when compared to the control group. A statistical significant lower mean of total protein and HDL in compare to control. result revealed a statistical significant higher mean of cupper in patient group  in compare to control and a significant lower mean of iron in patient group  in compare to control . Conclusion: The results included in this study showed dyslipidemia, renal disfunction and icrease in copper and iron due to the long duration of diabetes mellitus and the complication of disease.