Background: Morbid obesity has become a serious health problem due to its fatal consequences ‎and co-morbidities. It is well-accepted that obesity-related comorbidities may be effectively managed by bariatric surgery‎. Objective: The aim of the current study is to assess the outcomes of laparoscopic sleeve gastrectomy (LSG) ‎in morbidly ‎obese patients, regarding weight loss, effects on associated comorbidities ‎and post-operative complications. Patients and methods: Our retrospective cohort study was conducted in Sohag University Hospitals. A total of 60 patients who underwent LSG were followed up in the period from January 2017 to May 2018. Participants were patients with BMI ≥40 or BMI = 35–39 with one or more obesity-related co-morbidities. Results: Statistically significant weight reduction occurred at 3, 6, 12, 18 and 24 months after LSG. Regarding the comorbidities, we found that 12 cases had diabetes (4 cases improved and 8 reached remission). The mean HbA1c was within the prediabetic or the controlled diabetic zone for the vast majority of cases, and 6 cases had Hypertension, improvement occurred in 5 cases and one case reached remission. All cases that had dyslipidemia in the study population (5 cases) were completely controlled. Conclusion: LSG can be considered an effective single-stage procedure in morbidly obese patients showing excellent and reliable ‎results for weight loss in obese patients with a significantly low ‎complication rate. This procedure could significantly resolve obesity-related ‎morbidity.‎