Background: A common endocrine condition known as hypothyroidism is characterised by insufficient thyroid hormone production by the thyroid gland. Nearly all tissues need thyroid hormones for optimal growth, development, and operation, and the kidneys especially depend on them for healthy growth and operation. Thyroid dysfunction and uric acid (UA) metabolism may be related, according to some studies. A rise in serum uric acid (UA) levels may result from thyroid disease's impact on the purine metabolism. Objective: To examine the connection between thyroid hormones and blood uric acid in people with primary hypothyroidism. Patients and methods: This case-control comparative study was carried out at the Internal Medicine Department, Faculty of Medicine, Zagazig University. 126 subjects with similar age and sex distribution participated in the study. They were divided into three groups: 42 people with subclinical hypothyroidism, 42 people with overt hypothyroidism, and 42 healthy people (control individuals). Results: A statistically significant difference existed between the groups that were being researched in uric acid level. Post hoc test showed that there was a highly statistical significance increase in uric acid in hypothyroidism group compared to the subclinical hypothyroidism and control. In addition, there was a statistically significant rise in uric acid levels in the subclinical hypothyroidism group compared to the control group. Conclusion: Compared to euthyroid controls, blood uric acid levels are higher in overt hypothyroid and subclinical hypothyroid individuals.