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287321

Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals

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Last updated: 03 Jan 2025

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Abstract

Background: Hepatitis C virus HCV infection is one of the main causes of chronic liver disease worldwide, Egypt has the highest national-level HCV prevalence in the world, and direct Acting Antivirals are widely used to treat HCV infection in Egypt. Aim: To perform a long-term follow-up of patients with chronic hepatitis C who received IFN free regimen of direct-acting antivirals (DAAs). The follow-up aimed to study the incidence of hepatocellular carcinoma, viral recurrence in this cohort of patients and improvement of liver biochemicals or liver decompensation. Methodology: We recruited 1041 Egyptian HCV patients, who finished treatment more than 1 year before recruitment and then we assessed the improvement of the biochemical profile and the liver condition, incidence of occurrence or recurrence hepatocellular carcinoma after treatment. Results: The follow-up values of ALT, AST, INR, Bilirubin, Platelets and fibrosis-4 (Fib-4) showed a statistically significant improvement more than 1 year after treatment, while the improvement in albumin and AFP was noted without statistical significancy. By comparing the different groups of the study, patients with advanced liver disease showed a greater improvement in those parameters. However, they carried an increased risk of developing hepatocellular carcinoma. Conclusion: Achieving SVR using DAAs can improve liver functions tests, AFP, platelet count and FIB-4 value and persons with severe liver disease should be advised to undergo HCC surveillance after achieving sustained virological response (SVR).  

DOI

10.21608/ejhm.2023.287321

Keywords

HCV, DAAs, long-term, Hepatitis C virus

Authors

First Name

Ahmed

Last Name

Tawheed

MiddleName

-

Affiliation

-

Email

ahmed.tawhid14@gmail.com

City

-

Orcid

0000-0002-9382-8733

First Name

Mohamed

Last Name

El-Kassas

MiddleName

-

Affiliation

-

Email

m_elkassas@yahoo.com

City

-

Orcid

0000-0002-3396-6894

First Name

Amr

Last Name

El-Fouly

MiddleName

-

Affiliation

-

Email

fouly.amr@proton.me

City

-

Orcid

-

First Name

Gamal

Last Name

Esmat

MiddleName

-

Affiliation

-

Email

ahmed.tawhid77@gmail.com

City

-

Orcid

-

Volume

90

Article Issue

2

Related Issue

39562

Issue Date

2023-01-01

Receive Date

2023-02-25

Publish Date

2023-01-01

Page Start

2,767

Page End

2,774

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 90_Issue 2_Pages 2767-2774.pdf

PDF . 275.7kB

Link

https://ejhm.journals.ekb.eg/article_287321.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=287321

Order

117

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals

Details

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Article

Created At

24 Dec 2024