Background: One of the scoring methods used to assess organ failure is the Sequential Organ Failure Assessment (SOFA) score, which can forecast the severity and course of the illness. It is currently utilised as a crucial indicator for determining if a patient has sepsis syndrome. Objective: This study aimed to assess the prognostic predictive performance of a new indicator, SOFAComb calculated by SOFAΔ + absolute SOFA score in critically ill patients in the Emergency Department at Suez Canal University Hospital. Patients and Methods: This was a descriptive cross-sectional study conducted on 124 patients aged 18 years and above who attended the Emergency Department (ED) at Suez Canal University Hospital, Ismailia, Egypt diagnosed with sepsis. Results: The patients' ages varied from 86 to 104 years, with a mean age of 62.6 years. Male participants made up 46% of the study and female participants made up 54%. In terms of predicting mortality in sepsis patients, the SOFAComb outperformed SOFA in terms of sensitivity, specificity, and positive predictive value (PPV). While SOFAΔ outperformed both in terms of PPV and specificity. Conclusion: The SOFAComb presented a good predictive tool for patient outcome.