Introduction: Chemically, lipoic acid (LA) is (R)-5-(1,2-dithiolan-3-yl)pentanoic acid, and it is a naturally occurring substance (1-3). Lipoic acid has an amphipathic feature and is primarily a lipophilic molecule. Objective: The aim of the current study was to examine the preventive effects of ALA on certainbiological cardiac markers and histology of heart and aorta in rabbits. Subjects and methods: A total of 20 rabbits were divided into four groups: Rabbits in Group 1 (G1) were given distilled water. The rabbits in Group 2 (G2) were given alpha lipoic acid orally. Group 3 (G3) rabbits receivedMethandienone. Group 4 (G4) rabbits receivedMethandienone (0.35mg/kg.B.wt) and alpha lipoic acid (10Mg/kg B.wt) orally. Results: The results reveal that supplemented groups (G2 and G4) show a significant decrease in CPK, CRP and troponin serum level. Moreover, there is an increase in heart index (0.45% and 0.41%) as compared with none supplemented groups (0.43% and 0.35%) respectively. The histological sections of the heart from the supplemented groups show no clear lesions with normal spindle shape cardiac muscle and intercalated disc with normal aorta and epithelial cells. On the other hand, there was clear necrosis of cardiac muscle fibers with fatty dispassion, irregular myocardial endothelial degeneration and congested blood vessels. The aorta of these groups has enlargement and thickening of endothelial cells with infiltration of fatty cells in tunica intima. Conclusions: ALA has a protection on cardiovascular system.