Background: Androgens cause a progressive shortening of the anagen phase of hair growth, leading to the pattern of thinning hair known as androgenetic alopecia (AGA) in genetically predisposed men and women. Multiple biochemical processes allow activated platelet rich plasma (PRP) to promote stem cell proliferation and differentiation in the hair follicle bulge. Objective: Review of the literature on role of platelet rich plasma in treatment of androgenetic alopecia. Methods: These databases were searched for articles published in English in 3 data bases [PubMed – Google scholar- Egyptian Knowledge Bank] and Boolean operators (AND, OR, NOT) had been used such as [Platelet Rich Plasma AND Androgenetic alopecia OR AGA]  and in peer-reviewed articles between October 2001 and October 2022; a 21-year date range was selected, and no language limitations. Documents in a language apart from English have been excluded as sources for interpretation was not found. Papers apart from main scientific studies had been excluded: documents unavailable as total written text, conversation, conference abstract papers and dissertations. Conclusion: Blood flow to hair follicles is improved thanks to the platelet-rich plasma's ability to regulate angiogenesis. It has antiapoptotic and mitogenic actions that keep dermal papillae alive for longer, making it a promising treatment for alopecia. Evidence from the included clinical studies suggests that PRP therapy can be an effective treatment for AGA. Downtime, adverse effects, and potential safety concerns appear to be low.