Background: The leading cause of death in the world is coronary heart disease. Acute coronary syndrome (ACS) patients can have their in-hospital outcomes evaluated using the tissue Doppler imaging metric known as net atrioventricular compliance. Objective: The aim of the current study is to assess relation between net atrioventricular compliance and in hospital outcome in ACS patients.Patients and methods: A cross sectional study was conducted in Zagazig University Hospital, Cardiology Department on patients with ACS. Patients with atrial fibrillation, a history of moderate or severe valve stenosis or regurgitation, and myocardial infarction, poor echocardiographic picture quality, and refusal to participate to the study, significant congenital heart disease or left ventricular hypertrophy were excluded from the study.Detection of outcome of patients (arrhythmia, death, improvement) was assessed through their hospital stay. Results: Multivariate logistic regression predictors, in hospital complications among patients with ACS, showed that Cn level ≥11.65 and decrease EF% were significantly independent predictors in hospital complications among ACS patients. Conclusion: Net atrioventricular compliance can be used as independent predictors in hospital complications among patients with ACS.