Background: Patients on hemodialysis have drastically lowered immune systems. Particularly in people with compromised immune systems, intestinal parasites can cause severe morbidity and death. Objective: In Sohag Governorate, this case-control study examined the probabilities and prevalence rates of intestinal parasite infections in hemodialysis patients. Material and methods: This case-control study was carried out on 100 hemodialysis cases and 100 healthy control, the median was 55 years IQ (45:55), and control the median age was 39 IQ(30-45). Formol ether sedimentation concentration method, Modified Kinyoun's Acid-Fast Stain (cold), and direct wet mount and iodine stained smear were used to analyze the three fecal samples taken from each patient. Results: The present study observed a very highly significant statistical difference between cases and controls as regards single or mixed or no intestinal parasitic infection, the mixed intestinal parasitic infection was the main type in the cases group, while, most of the controls were non_infected or single type of infection, parasitic infection in hemodialysis patients was significantly higher about 4.7 more times than controls. Conclusions: Patients on hemodialysis with weakened immune systems brought on by chronic renal disease are more vulnerable to parasite infections. The findings of the current study demonstrated that intestinal parasites were much more common in hemodialysis patients.